Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary
K. Grace Foley, Michele T. Pritchard, Francesca E. Duncan
Abstract
Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.
Topics & Concepts
InflammationGiant cellMacrophageMultinucleateOvaryBiologyImmune systemPopulationSenescenceImmunologyPathologyCell biologyMedicineEndocrinologyGeneticsIn vitroEnvironmental healthReproductive System and PregnancyImmune cells in cancerImmune Cell Function and Interaction