Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates
Hayley R. Nordstrom, Daniel R. Evans, Amanda Finney, Kevin J. Westbrook, Paula F. Zamora, Casey E. Hofstaedter, Mohamed Yassin, Akansha Pradhan, Alina Iovleva, Robert K. Ernst, Jennifer M. Bomberger, Ryan K. Shields, Yohei Doi, Daria Van Tyne
Abstract
on CF airway epithelial cells. Overall, this study demonstrates how systematic genomic and phenotypic characterization can be deployed to develop bacteriophages as precision antibiotics.
Topics & Concepts
Lytic cyclePseudomonas aeruginosaPhage therapyBiologyBacteriophageMicrobiologyGenomeAntibioticsBacteriaVirologyGeneGeneticsVirusEscherichia coliBacteriophages and microbial interactionsGenomics and Phylogenetic StudiesMicrobial infections and disease research