TFAP2A-activated ITGB4 promotes lung adenocarcinoma progression and inhibits CD4+/CD8+ T-cell infiltrations by targeting NF-κB signaling pathway
Cheng Pan, Zhibo Wang, Qi Wang, Hongshun Wang, Xiaheng Deng, Liang Chen, Zhihua Li
Abstract
Background: ) in the progression and immune microenvironment of lung adenocarcinoma (LUAD). Methods: was evaluated using nude mice. Additionally, its effect on T cell infiltration was studied using immunocompetent C57BL/6J mice. Results: signaling. Conclusions: may serve as a potential immunotherapeutic target of LUAD.
Topics & Concepts
MedicineCancer researchNF-κBLungSignal transductionAdenocarcinomaLung cancerNFKB1CD8ImmunologyCell biologyCancerPathologyInflammationTranscription factorInternal medicineBiologyImmune systemGeneGeneticsPeptidase Inhibition and AnalysisRNA modifications and cancerNF-κB Signaling Pathways