Litcius/Paper detail

Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment

Qingqing Guo, Huimin Zhang, Yanhong Deng, Shiyang Zhai, Zhenla Jiang, Daqian Zhu, Ling Wang

2020European Journal of Medicinal Chemistry33 citationsDOI

Topics & Concepts

ColchicineTubulinHeLaChemistryMicrotubuleDocking (animal)Small moleculeVirtual screeningCytotoxicityIC50Binding siteIn vitroApoptosisDrug discoveryBiochemistryPharmacologyCell biologyBiologyNursingGeneticsMedicineComputational Drug Discovery MethodsSynthesis and biological activityMicrobial Natural Products and Biosynthesis