Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment
Qingqing Guo, Huimin Zhang, Yanhong Deng, Shiyang Zhai, Zhenla Jiang, Daqian Zhu, Ling Wang
Topics & Concepts
ColchicineTubulinHeLaChemistryMicrotubuleDocking (animal)Small moleculeVirtual screeningCytotoxicityIC50Binding siteIn vitroApoptosisDrug discoveryBiochemistryPharmacologyCell biologyBiologyNursingGeneticsMedicineComputational Drug Discovery MethodsSynthesis and biological activityMicrobial Natural Products and Biosynthesis