Non-Coding RNAs as Prognostic Markers for Endometrial Cancer
Roberto Piergentili, Simona Zaami, Anna Franca Cavaliere, Fabrizio Signore, Giovanni Scambia, Alberto Mattei, Enrico Marinelli, Caterina Gulìa, Federica Perelli
Abstract
Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are emerging as promising markers in several cancer types, including EC, for which their prognostic value is currently under investigation and will likely integrate the present prognostic tools based on protein coding genes. This review aims to underline the importance of the genetic and epigenetic events in the EC tumorigenesis, by expounding upon the prognostic role of ncRNAs.