Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology
Jinbo Cheng, Yuan Dong, Jun Ma, Rui‐Yuan Pan, Yajin Liao, Xiangxi Kong, Xiaoheng Li, Shuoshuo Li, Ping-Fang Chen, Liang Wang, Ye Yu, Zengqiang Yuan
Abstract
reduced acute LPS-induced neuroinflammation. These results highlight an important role for Calhm2 in microglial activation and provide a potential therapeutic target for diseases related to microglia-mediated neuroinflammation.
Topics & Concepts
NeuroinflammationMicrogliaDiseasePathologyTau pathologyMedicineNeuroscienceAlzheimer's diseaseBiologyInflammationImmunologyNeuroinflammation and Neurodegeneration MechanismsS100 Proteins and AnnexinsAlzheimer's disease research and treatments