Easy synthesis of imidazo[1,5-<i>a</i>]indol-3-ones through Rh(<scp>iii</scp>)-catalyzed C–H allenylation/annulation
Bin Zhu, Zhenyu Yao, Lang Huang, Xiuling Cui
Abstract
A highly efficient and regioselective synthesis of imidazo[1,5- a ]indol-3-ones has been developed via a sequential C – H allenylation/annulation starting from easily available N -methoxycarbamoyl indoles and propargyl alcohols, in which the propargyl alcohols served as a C1 synthon.
Topics & Concepts
AnnulationRegioselectivityPropargylSynthonChemistryCatalysisSubstrate (aquarium)Combinatorial chemistryAtom economyStereochemistryScope (computer science)Organic chemistryComputer scienceProgramming languageOceanographyGeologyCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions