Aureonitol Analogues and Orsellinic Acid Esters Isolated from <i>Chaetomium elatum</i> and Their Antineuroinflammatory Activity
Feng Ju, Qi-Xuan Kuang, Qingzhou Li, Li-Jun Huang, Wenxiu Guo, Lei-Qiang Gong, Yifei Dai, Lun Wang, Yu‐Cheng Gu, Dong Wang, Yun Deng, Da‐Le Guo
Abstract
decreases the level of inducible nitric oxide synthase and cyclooxygenase-2 and suppresses the expression of Toll-like receptor 4 and nuclear factor kappa-B (NF-κB) as well as the phosphorylation of the inhibitor of NF-κB and p38 mitogen-activated protein kinases in lipopolysaccharide-activated BV-2 microglial cells.
Topics & Concepts
Circular dichroismStereochemistryNitric oxideChemistryNitric oxide synthaseWestern blotKinaseBiochemistryp38 mitogen-activated protein kinasesEnzymeProtein kinase AOrganic chemistryGeneAlkaloids: synthesis and pharmacologyTraditional and Medicinal Uses of AnnonaceaeBioactive natural compounds