Tumor-associated macrophages promoting PD-L1 expression in infiltrating B cells through the CXCL12/ CXCR4 axis in human hepatocellular carcinoma
Senlin Lian
Abstract
Bregs. At last, we confirmed the communications among CAFs, Macrophages and B cells and their tumor-promoting effects by using an orthotopic mouse model of HCC. Immunosuppressive HCC TME involving cell-to-cell communications comprised MIF-secreting CAFs, CXCL12-secreting TAMs, and PD-L1-producing Bregs, and their regulation could be promising therapeutic targets in future immunotherapy for human HCC.
Topics & Concepts
Hepatocellular carcinomaCancer researchCXCR4MedicinePathologyChemokineImmunologyImmune systemCancer Immunotherapy and BiomarkersImmune cells in cancerImmune Cell Function and Interaction