Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme
Lukas Kahlert, Miranda Villanueva, Russell J. Cox, Elizabeth Skellam
Abstract
The polyketide synthase (PKS)-like protein TerB, consisting of inactive dehydratase, inactive C-methyltransferase, and functional ketoreductase domains collaborates with the iterative non reducing PKS TerA to produce 6-hydroxymellein, a key pathway intermediate during the biosynthesis of various fungal natural products. The catalytically inactive dehydratase domain of TerB appears to mediate productive interactions with TerA, demonstrating a new mode of trans-interaction between iterative PKS components.
Topics & Concepts
Polyketide synthaseDehydratasePolyketideBiosynthesisEnzymeBiochemistryChemistryStereochemistryComputational biologyBiologyMicrobial Natural Products and BiosynthesisMycorrhizal Fungi and Plant InteractionsFungal Biology and Applications