Kidney stone formation in a novel murine model of polycystic kidney disease
Heather A. Riddle, Shiqin Zhang, Feng Qian, James C. Williams, Jason R. Stubbs, Peter Rowe, Stephen C. Parnell
Abstract
mice were found to form calcium phosphate-containing stones within cysts of the renal cortex by 13 wk of age. This is the first polycystic kidney disease animal model exhibiting spontaneous stone formation. A growing body of evidence suggests a link between renal stone formation and cystic kidney disease. This mouse model may be useful for studying the interplay between stone and cyst formation and the functional role of polycystins in mineral homeostasis.
Topics & Concepts
Polycystic kidney diseasePKD1Kidney stonesKidney stone diseaseKidneyCystAutosomal dominant polycystic kidney diseaseKidney diseaseDiseaseNephrologyInternal medicineHomeostasisEndocrinologyMedicinePathologyBiologyGenetic and Kidney Cyst DiseasesBiomedical Research and PathophysiologyPediatric Urology and Nephrology Studies