Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
Jairus L. Lamola, Paseka T. Moshapo, Cedric W. Holzapfel, Munaka Christopher Maumela
Abstract
A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki-Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature.
Topics & Concepts
PalladiumPhosphineChemistryCoupling (piping)Coupling reactionCombinatorial chemistryMedicinal chemistryPolymer chemistryOrganic chemistryCatalysisMaterials scienceMetallurgyCatalytic Cross-Coupling ReactionsChemical synthesis and alkaloidsCatalytic C–H Functionalization Methods