Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis
Oshadhi T. Jayasinghe, Zachary F. Mandell, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke
Abstract
NusA is an essential transcription elongation factor that was assumed to play a major role in RNAP pausing. NusA stimulates pausing in vitro ; however, the essential nature of NusA had prevented an assessment of its role in pausing in vivo .
Topics & Concepts
BiologyRNA polymeraseBacillus subtilisTranscription (linguistics)RNAGeneticsRNase PSigma factorCell biologyGeneTranscription factorElongation factorRibosomeBacteriaLinguisticsPhilosophyRNA and protein synthesis mechanismsRNA modifications and cancerRNA Research and Splicing