Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors
Michael Plewe, Vidyasagar Reddy Gantla, Н.В. Соколова, Young-Jun Shin, Shibani Naik, Eric Brown, Alexandra Fetsko, Lihong Zhang, Birte Kalveram, Alexander N. Freiberg, Greg Henkel, Ken McCormack
Topics & Concepts
ArenavirushERGChemistryBroad spectrumLead compoundChemical synthesisCombinatorial chemistryEnzymeDrug discoveryMetabolic stabilityStereochemistryIn vitroBiochemistryBiologyBiophysicsPotassium channelCytotoxic T cellLymphocytic choriomeningitisViral Infections and Outbreaks ResearchViral Infections and VectorsSARS-CoV-2 and COVID-19 Research