A nitrosyl iron complex with 3.4-dichlorothiophenolyl ligands: synthesis, structures and its reactions with targets – carriers of nitrogen oxide (NO) <i>in vivo</i>
Оlesya V. Pokidova, Veronika O. Novikova, N. S. Emel’yanova, Alexandra Yu. Kormukhina, А. В. Куликов, А. Н. Утенышев, Vladimir A. Lazarenko, N. S. Ovanesyan, Arina A. Starostina, Natalya A. Sanina
Abstract
). In this case, the complex becomes a prolonged NO-donor. Such a long-term effect has been observed for the first time. Similarly, in a system with oxyhemoglobin, NO generation is slower; the UV-vis spectra show a gradual formation of methemoglobin. On the other hand, reduced glutathione has little effect on the NO-donor properties of the complex despite the fact that ligand substitution is observed in the system and a binuclear product is formed. Mucin binds the complex, and the decomposition mechanism is different from that for buffer solutions. Thus, these proteins and glutathione are able to participate in the transformation of the complex and modulate its properties as a potential drug.