TroR Negatively Regulates the TroABCD System and Is Required for Resistance to Metal Toxicity and Virulence in Streptococcus suis
Chengkun Zheng, Man Wei, Jun Qiu, Mengdie Jia, Xiaohui Zhou, Xinan Jiao
Abstract
operon, which has been demonstrated to be involved in manganese acquisition in S. suis. Moreover, we demonstrated that TroR is required for the virulence of S. suis in an intranasal mouse model. Collectively, these results suggest that TroR is a negative regulator of the TroABCD system and contributes to resistance to metal toxicity and virulence in S. suis.
Topics & Concepts
Streptococcus suisVirulenceMicrobiologyPathogenBacteriaBiologyStreptococcusToxicityMetal toxicityChemistryGeneticsGeneOrganic chemistryStreptococcal Infections and TreatmentsNeonatal and Maternal InfectionsAntimicrobial Resistance in Staphylococcus