Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis
Minglong Liu, Richard Morewood, Ryoji Yoshisada, Mirte N. Pascha, Antonius J. P. Hopstaken, Eliza Tarcoveanu, David A. Poole, Cornelis A. M. de Haan, Christoph Nitsche, Seino A. K. Jongkees
Abstract
A new tool for peptide discovery. Pyridine-nitrile based macrocyclisation in mRNA display format, provides novel conformational constraints and allows construction of controlled bicyclic structures.
Topics & Concepts
Bicyclic moleculeNitrileThiazolinePeptidePyridineMessenger RNAChemistryCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryGeneChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchRNA and protein synthesis mechanisms