Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism
Fabrice Lejeune
Abstract
Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.
Topics & Concepts
Nonsense-mediated decayGeneNonsenseBiologyMessenger RNAMechanism (biology)Cell biologyRegulation of gene expressionGene expressionGeneticsRNAEpistemologyRNA splicingPhilosophyRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer