Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis
Zhaohui Liu, Yanli Meng, Yu Rebecca Miao, Lili Yu, Qiannan Yu
Abstract
in rat alveolar macrophages incubated with serum from the rI/R rat model. These findings indicate that propofol attenuates rI/R-induced ALI by suppressing pyroptosis, possibly by upregulating SIRT1 in the lungs.
Topics & Concepts
PyroptosisMedicinePropofolIschemiaReperfusion injurySirtuin 1LungAcute kidney injuryRenal ischemiaSirtuinPharmacologyAnesthesiaCardiologyInternal medicineInflammationChemistryInflammasomeDownregulation and upregulationGeneBiochemistryAcetylationInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideThermal Regulation in Medicine