Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia
Xuena Bo, Fei Xie, Jingdan Zhang, Run-Ze Gu, Xiaoheng Li, Shuoshuo Li, Zengqiang Yuan, Jinbo Cheng
Abstract
We demonstrate the important role of Calhm2 in microglial activation and the pathology of PD, thus providing a potential therapeutic target for microglia-mediated neuroinflammation-related diseases.
Topics & Concepts
MicrogliaNeuroinflammationKnockout mouseMPTPGene knockdownWestern blotInflammationDopaminergicCell biologyNeuroscienceBiologyMedicineImmunologyDopamineReceptorInternal medicineCell cultureBiochemistryGeneGeneticsNeuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling