The AlphaFold Database of Protein Structures: A Biologist’s Guide
Alessia David, Suhail A. Islam, Evgeny Tankhilevich, Michael J.E. Sternberg
Abstract
AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology.
Topics & Concepts
BiologistPerspective (graphical)Computer scienceData scienceComputational biologyProteomeBiologyArtificial intelligenceBioinformaticsGeneticsMachine Learning in BioinformaticsProtein Structure and DynamicsRNA and protein synthesis mechanisms