Litcius/Paper detail

<sup>18</sup>F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism

Lisa J. States, James C. Davis, Steven Hamel, Susan Becker, Hongming Zhuang

2021Journal of Nuclear Medicine17 citationsDOIOpen Access PDF

Abstract

Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. <sup>18</sup>F-6-fluoro-l-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of <sup>18</sup>F-6-fluoro-l-dopa PET/CT in the management of this vulnerable population.

Topics & Concepts

Congenital hyperinsulinismHypoglycemiaMedicineHyperinsulinismHyperinsulinemic hypoglycemiaLesionInsulinPopulationPancreatectomyPet imagingPancreasRadiologyPositron emission tomographyNuclear medicineInternal medicineSurgeryInsulin resistanceEnvironmental healthHyperglycemia and glycemic control in critically ill and hospitalized patientsMedical Imaging Techniques and ApplicationsNeuroblastoma Research and Treatments