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A sub-ppbv-level Acetone and Ethanol Quantum Cascade Laser Based Photoacoustic Sensor – Characterization and Multi-Component Spectra Recording in Synthetic Breath

Jonas Pangerl, Elisabeth Moser, Max Müller, Stefan Weigl, Simon Jobst, Thomas Rück, Rudolf Bierl, Frank‐Michael Matysik

2023Photoacoustics17 citationsDOIOpen Access PDF

Abstract

Trace gas analysis in breath is challenging due to the vast number of different components. We present a highly sensitive quantum cascade laser based photoacoustic setup for breath analysis. Scanning the range between 8263 and 8270 nm with a spectral resolution of 48 pm, we are able to quantify acetone and ethanol within a typical breath matrix containing water and CO2. We photoacoustically acquired spectra within this region of mid-infra-red light and prove that those spectra do not suffer from non-spectral interferences. The purely additive behavior of a breath sample spectrum was verified by comparing it with the independently acquired single component spectra using Pearson and Spearman correlation coefficients. A previously presented simulation approach is improved and an error attribution study is presented. With a 3σ detection limit of 6.5 ppbv in terms of ethanol and 250 pptv regarding acetone, our system is among the best performing presented so far.

Topics & Concepts

Quantum cascade laserSpectral linePhotoacoustic imaging in biomedicineLaserDetection limitAnalytical Chemistry (journal)CascadeMaterials scienceBreath gas analysisAcetoneSpectral resolutionTrace gasOpticsChemistryPhysicsChromatographyMeteorologyAstronomyOrganic chemistrySpectroscopy and Laser ApplicationsAdvanced Chemical Sensor TechnologiesAnalytical Chemistry and Sensors
A sub-ppbv-level Acetone and Ethanol Quantum Cascade Laser Based Photoacoustic Sensor – Characterization and Multi-Component Spectra Recording in Synthetic Breath | Litcius