Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition
Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen
Abstract
. In conclusion, Sa suppresses FOSL1 transcription by downregulating TCF7, thereby inhibiting MMP9 expression and ultimately reducing the renal inflammation and cell apoptosis induced by sepsis.
Topics & Concepts
Proinflammatory cytokineMMP9InflammationApoptosisMatrix metalloproteinaseBiologySepsisLipopolysaccharideCancer researchCell biologyDownregulation and upregulationImmunologyGeneBiochemistryAdvanced Glycation End Products researchS100 Proteins and AnnexinsATP Synthase and ATPases Research