Palladium-catalyzed highly chemoselective dearomative spirocyclization of Ugi adducts: facile access to functionalized benzoazepinespiroindolenines with diastereoselectivity
Chuan‐Hua Qu, Shu-Ting Li, Jianbo Liu, Dianyong Tang, Zhigang Xu, Zhong‐Zhu Chen, Gui‐Ting Song
Abstract
The development of chemoselective strategies for complex molecules is intrinsically challenging. In this paper, a facile and diversity-oriented access to benzoazepinespiroindolenines is elaborated via Pd-catalyzed highly chemoselective dearomative spirocyclization of Ugi adducts.
Topics & Concepts
AdductChemistryCatalysisCombinatorial chemistryPalladiumChemoselectivityMoleculeSmall moleculeOrganic chemistryBiochemistryCatalytic C–H Functionalization MethodsMulticomponent Synthesis of HeterocyclesSynthetic Organic Chemistry Methods