New 1<i>H</i>-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity
Maria Argirova, Miglena K. Georgieva, Nadya Hristova-Avakumova, Dimitar Vuchev, Galya Popova-Daskalova, Kameliya Anichina, Denitsa Yancheva
Abstract
The design of new drug candidates that combine anthelmintic and antioxidant actions in one molecule offers a beneficial approach in the treatment of the tissue damages, immune system dysfunction and oxidative stress caused by trichinellosis.
Topics & Concepts
ChemistryAnthelminticAntioxidantRadicalBenzimidazoleDPPHTrichinella spiralisOxidative stressABTSAntiparasiticStereochemistryOrganic chemistryBiochemistryBiologyImmunologyHelminthsPathologyMedicineEcologyFree Radicals and AntioxidantsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Biological Evaluation