Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models
Minru Liao, Qiang Xie, Yuqian Zhao, Chengcan Yang, Congcong Lin, Guan Wang, Bo Liu, Lingjuan Zhu
Topics & Concepts
AutophagyProtein kinase BPI3K/AKT/mTOR pathwayApoptosisNOX4Programmed cell deathPharmacologyHeart failureMedicineTLR4InflammationChemistryNADPH oxidaseImmunologyInternal medicineBiochemistryOxidative stressAutophagy in Disease and TherapyIntracerebral and Subarachnoid Hemorrhage ResearchAdenosine and Purinergic Signaling