Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19
Sangya Agarwal, Carl H. June
Abstract
Cytokine release and macrophage activation contribute to immunopathology after SARS-CoV-2 infection. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)RepurposingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakDrug repositioningImmunopathologyMedicineCytokineImmunologyBetacoronavirusT cellVirologyComputational biologyBioinformaticsBiologyImmune systemPharmacologyInternal medicineDrugEcologyInfectious disease (medical specialty)OutbreakDiseaseCOVID-19 Clinical Research StudiesCAR-T cell therapy researchSARS-CoV-2 and COVID-19 Research