Inhibition of Tumor Metastasis by Liquid‐Nitrogen‐Shocked Tumor Cells with Oncolytic Viruses Infection (Adv. Mater. 28/2023)
Qing Wu, Hanwei Huang, Mengchi Sun, Ruizhe Zhang, Junxia Wang, Hanqi Zheng, Chaojie Zhu, Shihua Yang, Xinyuan Shen, Jiaqi Shi, Feng Liu, Wei Wu, Jin Sun, Funan Liu, Hongjun Li, Zhen Gu
Abstract
Drug Delivery In article number 2212210, Funan Liu, Hongjun Li, Zhen Gu, and co-workers present an oncolytic virus therapy that can target metastasis after systemic administration. Tumor cells that have been pre-infected with an oncolytic virus serve as the delivery vehicle after pathogenicity has been eliminated by liquid nitrogen shock, but their metastasis-targeting ability is maintained by the integrity of cellular structure and surface protein preservation. This Trojan-horse-like method prevents virus neutralization and clearance in the bloodstream and improves tumor-specific delivery.