Cysteamine mitigates torsion/detorsion‐induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model
Oladele Ayobami Afolabi, Babatunde Alabi, Temidayo Olutayo Omóbòwálé, Olufemi I. Oluranti, Olugbenga Iwalewa
Abstract
MDA and nitrite but reduction in SOD, GPx, GSH, GST and total thiol in the testicular tissue of IRI rats was reversed by cysteamine. Serum MPO and TNF-α were significantly elevated in RI, while treated-RI rats showed decrease (p < .05) in tissue level of the inflammation markers. Reduced sperm motility in RI was significantly reversed by cysteamine. Increased tissue expression of bax and caspase-3 was reversed by cysteamine. Cysteamine protected the testis against reperfusion injury through anti-inflammatory, antioxidant effects and inhibition of apoptosis in rats.
Topics & Concepts
CysteamineOxidative stressChemistryMalondialdehydeApoptosisSuperoxide dismutaseReperfusion injuryEndocrinologyPharmacologyGlutathioneTesticular torsionInflammationInternal medicineMedicineIschemiaBiochemistrySurgeryEnzymeTesticular diseases and treatmentsSperm and Testicular FunctionPharmacological Effects and Toxicity Studies