Bioassay-guided isolation of terpenoids from the soft coral <i>Sclerophytum humesi</i> and assessment of their antidiabetic and cytotoxic activities
Luu Vu Phuong, Quoc-Dung Tran Huynh, Ngoc-Thac Pham, Huong-Giang Le, Lo-Yun Chen, Cường Quốc Nguyễn, Huong Lien Ton-Nu, Mei‐Hsien Lee, Yu‐Chia Chang, Jui-Hsin Su, Bo‐Rong Peng, Kuei-Hung Lai
Abstract
values of 2.52 ± 0.27 μM and 2.54 ± 0.38 μM, respectively. Enzyme kinetics, molecular docking, and molecular dynamics simulations were also performed to further elucidate the experimental findings. These results underscore the potential of marine-derived terpenoids as promising multifunctional bioactive agents with therapeutic applications in the management of diabetes, obesity, and pancreatic cancer.
Topics & Concepts
CoralTerpenoidBioassayTraditional medicineCytotoxic T cellChemistryIsolation (microbiology)StereochemistryBiologyBiochemistryMedicineIn vitroMicrobiologyEcologyMarine Sponges and Natural ProductsSeaweed-derived Bioactive CompoundsAquaculture Nutrition and Growth