Iron-Catalyzed, Site-Selective Difluoromethylthiolation (−SCF<sub>2</sub>H) and Difluoromethylselenation (−SeCF<sub>2</sub>H) of Unactivated C(sp<sup>3</sup>)–H Bonds in <i>N</i>-Fluoroamides
Hongwei Zhang, Fei Yu, Chuang Li, Peiyuan Tian, Yulu Zhou, Zhong‐Yan Cao
Abstract
The iron-catalyzed δ-C(sp3)–H bond difluoromethylthiolation and difluoromethylselenation of aliphatic amides with high site selectivity are reported. Essential to the success is the employment of an amide radical formed in situ to activate the inert C(sp3)–H bond and the utilization of the easily handled PhSO2SCF2H and PhSO2SeCF2H as coupling reagents under mild conditions. This scalable protocol exhibits a broad substrate scope bearing versatile functional groups. Mechanistic studies indicate that the reaction proceeds through −SCF2H and −SeCF2H radical transfer.
Topics & Concepts
ChemistryCatalysisReagentAmideSubstrate (aquarium)Combinatorial chemistrySelectivityInertMedicinal chemistryStereochemistryOrganic chemistryOceanographyGeologyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds