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Copper-catalyzed alkylarylation of vinylarenes with cycloalkylsilyl peroxides and boronic acids

Shuo Yang, Pin Gao, Meng-Ting Suo, Shu‐Xin Gao, Xin‐Hua Duan, Li‐Na Guo

2020Chemical Communications36 citationsDOI

Abstract

A mild copper-catalyzed alkylarylation of vinylarenes with cycloalkylsilyl peroxides and boronic acids is described. This three-component protocol provides a straightforward approach to the remote keto-functionalized 1,1-diarylmethane derivatives. A radical pathway initiated by C-C bond cleavage is proposed for this tandem reaction.

Topics & Concepts

CatalysisChemistryCopperCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryCatalytic Cross-Coupling Reactions
Copper-catalyzed alkylarylation of vinylarenes with cycloalkylsilyl peroxides and boronic acids | Litcius