T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Jie Yan, Surya Pandey, Betsy Barnes, Jerrold R. Turner, Clara Abraham
Abstract
T cells from high IRF5-expressing disease-risk genetic carriers demonstrate increased chemokine-induced migration and Th1/Th17 cytokines and reduced Th2-associated and anti-inflammatory cytokines. These data demonstrate key roles for T cell-intrinsic IRF5 in inflammatory outcomes.
Topics & Concepts
IRF5BiologyImmunologyChemokineT cellInflammationCell biologyImmune systemInterferon regulatory factorsCancer researchInnate immune systemImmune Cell Function and InteractionCytokine Signaling Pathways and InteractionsImmune Response and Inflammation