Sulfation at Glycopolymer Side Chains Switches Activity at the Macrophage Mannose Receptor (CD206) In Vitro and In Vivo
Francesca Mastrotto, Marco Pirazzini, Samuele Negro, Alan D. Salama, Luisa Martínez‐Pomares, Giuseppe Mantovani
Abstract
-3-Gal glycopolymers inhibit CD206 both in vitro and in vivo, revealing hitherto unknown receptor function and demonstrating their potential as CD206 modulators within future immunotherapies.
Topics & Concepts
EctodomainMannose receptorGlycopolymerEndocytic cycleChemistryScavenger receptorIn vivoCell biologyReceptorMannoseIn vitroMacrophageBiochemistryEndocytosisBiologyLipoproteinOrganic chemistryCholesterolCopolymerPolymerBiotechnologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchRNA Interference and Gene Delivery