Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period
Amanda L. Ziegler, Madison L. Caldwell, Sara Erwin, Emily A. Hellstrom, Anastasia Sheridan, Mélissa Touvron, Tiffany Pridgen, Scott T. Magness, Jack Odle, Laurianne Van Landeghem, Anthony T. Blikslager
2023American Journal of Physiology-Gastrointestinal and Liver Physiology11 citationsDOIOpen Access PDF
Abstract
This study refines a powerful translational pig model, defining an age-dependent relationship between enteric glia and the intestinal epithelium during intestinal ischemic injury and confirming an important role for enteric glial cell (EGC) activity in driving mucosal barrier restitution. This study suggests that targeting the enteric glial network could lead to novel interventions to improve recovery from intestinal injury in neonatal patients.
Topics & Concepts
Enteric nervous systemRestitutionBarrier functionEpitheliumIntestinal mucosaMedicineIntestinal epitheliumPathologyBiologyImmunologyNeuroscienceCell biologyInternal medicinePolitical scienceLawAnesthesia and Neurotoxicity ResearchInfant Nutrition and HealthClinical Nutrition and Gastroenterology