Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV
Heba A. Hofny, Mamdouh F. A. Mohamed, Hesham A. M. Gomaa, Salah A. Abdel‐Aziz, Bahaa G. M. Youssif, Nawal El‐Koussi, Ahmed S. Aboraia
Topics & Concepts
DNA gyraseNovobiocinTopoisomeraseChemistryTopoisomerase IVTopoisomerase inhibitorQuinolineEscherichia coliAntibacterial activityDNAStereochemistryBiochemistryBacteriaBiologyAntibioticsOrganic chemistryGeneticsGeneCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation