Design, synthesis, and biological evaluation of a series of benzofuran[3,2-d]pyrimidine-4(3H)-one derivatives containing thiosemicarbazone analogs as novel PARP-1 inhibitors
Yuanjiang Wang, Kun Li, Wenqing Xu, Shao-Hua Gou
Topics & Concepts
Poly ADP ribose polymeraseChemistryOlaparibDNA repairBenzofuranPyrimidineDNADNA damagePolymeraseCancer cellApoptosisBiochemistryStereochemistryCancerBiologyGeneticsPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisDNA Repair Mechanisms