Synthesis of Pyrrolidine‐ and γ‐Lactam‐Containing Natural Products and Related Compounds from Pyrrole Scaffolds
Wesley J. Olivier, Jason A. Smith, Alex C. Bissember
Abstract
Polycyclic alkaloid natural products featuring pyrrolidine and pyrrolidinone motifs remain enduring targets of total synthesis endeavors. Pyrrole and its derivatives have been exploited to access many such frameworks, including alkaloids belonging to the Aspidosperma, Stemona, and batzelladine families. In this article, a selection of exemplars that highlight the utility of pyrrole-based approaches to facilitate total syntheses of pyrrolidine- and pyrrolidinone-containing alkaloids and related molecules are showcased.
Topics & Concepts
PyrrolidinePyrroleAspidospermaTotal synthesisChemistryAlkaloidCombinatorial chemistryStereochemistryOrganic chemistryIndole testAdvanced Synthetic Organic ChemistryChemical synthesis and alkaloidsPlant and fungal interactions