RGD-Peptide Functionalization Affects the <i>In Vivo</i> Diffusion of a Responsive Trimeric MRI Contrast Agent through Interactions with Integrins
G Gambino, Tanja Gambino, Liam Connah, Francesca La Cava, HC Evrard, Goran Angelovski
Abstract
coordination and demonstrated a longer retention time in the tissue due to the presence of the RGD moiety. The obtained results testify to the potential of combining bioresponsive contrast agents with targeting vectors to develop novel functional molecular imaging methods.
Topics & Concepts
ChemistryIntegrinMolecular imagingPeptideIn vivoMoietyBiophysicsMolecular probeBifunctionalReceptorCombinatorial chemistryBiochemistryStereochemistryCatalysisBiologyDNABiotechnologyNanoparticle-Based Drug DeliveryLanthanide and Transition Metal ComplexesCell Adhesion Molecules Research