Triggering self‐supplied nanocatalytic reaction on Ti <sub>3</sub> C <sub>2</sub> MXene@CaO <sub>2</sub> ‐TiO <sub>2‐x</sub> for synergistic oral cancer therapy, antibacterial infection, and bone regeneration
Chao Liu, Huiping Li, Guangxin Sun, Yucheng Wang, Jiahao Zhang, Xinyi Huang, Yu Chen, Xuzhuo Chen, Xiuming Liu, Zixian Jiao, Shanyong Zhang
Abstract
Abstract After oral carcinoma resection, postoperative cancer recurrence, bacterial infection, and craniomaxillofacial bone defect threaten patients’ health. Current treatment is mainly to repair bone defects by bone substitute implantation, but that ignores the side effects caused by residual tumor cells and oral bacteria. To reach a better therapeutic effect, this paper develops a novel self‐supplied catalytic nanocomposite (MX@Ca‐Ti) that mainly consists of Ti 3 C 2 MXene nanosheets and CaO 2 nanoparticles with the purpose of synergistically promoting osteogenesis, inhibiting tumor cell growth, and preventing bacterial infection. Herein, the CaO 2 activation creates TiO 2‐x with Ti 3+ and Ti 4+ on MX@Ca‐Ti, which is structurally composed of porous, monolayer nanosheet and TiO 2‐x nanodots. The self‐supplied catalytic effects of sonodynamic therapy by Ti 4+ and chemodynamic therapy by Ti 3+ , enhance the therapeutic efficiency of tumor recurrence and bacterial infection. More importantly, this nanocomposite is demonstrated to have good cytocompatibility and osteogenesis‐promoting capability because of the release of O 2 and Ca 2+ . In conclusion, MX@Ca‐Ti not only defeats tumor cells and bacteria but also strengthens osteogenesis, which is an ideal treatment for avoiding postoperative complications and promoting bone defect repair from an oral carcinoma excision.