Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi
Abstract
suppressed infection of HSV-1 (DNA virus) or Sendai virus (RNA virus) into human macrophages by enhancing antiviral immunity. Our finding highlights a beneficial role of Mn in nucleic-acid-based preventive or therapeutic reagents against infectious diseases.
Topics & Concepts
Innate immune systemSendai virusPhosphorylationNucleic acidDNATANK-binding kinase 1BiologyRNAKinaseImmune systemInterferonCell biologyChemistryMolecular biologyVirusVirologyBiochemistryGeneProtein kinase AImmunologyMitogen-activated protein kinase kinaseinterferon and immune responsesImmune Response and InflammationRNA regulation and disease