RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric Cancer
Zhijie Ma, Qi Sun, Chengfei Zhang, Qian Zheng, Yixuan Liu, Haojun Xu, Yiting He, Chengyun Yao, Jinfei Chen, Hongping Xia
Abstract
These results indicate that the upregulation of RHOJ contributes to EMT-subtype GC invasion and metastasis via IL-6/STAT3 signaling, and RHOJ is expected to become a promising biomarker and therapeutic target for EMT-subtype GC patients.
Topics & Concepts
Epithelial–mesenchymal transitionMetastasisGene knockdownAngiogenesisCancer researchImmunohistochemistryCancerBiologyCell cultureImmunologyGeneticsCancer-related molecular mechanisms researchMycobacterium research and diagnosisGastric Cancer Management and Outcomes