The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>
Richard J. Wall, Sandra Carvalho, Rachel Milne, Juan A. Bueren‐Calabuig, Sónia Moniz, Juan Cantizani-Perez, Lorna MacLean, Albane Kessler, Ignacio Cotillo, Lalitha Sastry, Sujatha Manthri, Stephen Patterson, Fabio Zuccotto, Stephen Thompson, Julio Martín, María Marco, Timothy J. Miles, Manu De Rycker, Michael G. Thomas, Alan H. Fairlamb, Ian H. Gilbert, Susan Wyllie
Abstract
with a propensity to rapidly mutate. Strategies to rapidly identify compounds acting via this mechanism are discussed to ensure that drug discovery portfolios are not overwhelmed with inhibitors of a single target.
Topics & Concepts
Trypanosoma cruziLeishmania donovaniLeishmaniaDrugTrypanosomaBiologyAntiparasitic agentChagas diseaseLeishmaniasisVirologyMicrobiologyParasite hostingVisceral leishmaniasisPharmacologyImmunologyComputer scienceWorld Wide WebTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesBiochemical and Molecular Research