An innovative rhein-matrine cocrystal: Synthesis, characterization, formation mechanism and pharmacokinetic study
Hongjuan Wang, Dezhi Yang, Wen Zhang, Junke Song, Ningbo Gong, Mingchao Yu, Shiying Yang, Baoxi Zhang, Qiwen Liu, Guanhua Du, Yang Lü
Topics & Concepts
CocrystalDifferential scanning calorimetrySolubilityBioavailabilityThermogravimetric analysisChemistryDissolutionActive ingredientFourier transform infrared spectroscopyPowder diffractionChemical engineeringNuclear chemistryMaterials scienceOrganic chemistryCrystallographyPharmacologyMoleculeMedicineHydrogen bondThermodynamicsPhysicsEngineeringCrystallography and molecular interactionsBiochemical effects in animalsMolecular spectroscopy and chirality