Streamlined synthesis of α-keto-, α-hydroxy- and α,α-difluorophosphonates from amides via electrophilic activation with trifluoromethanesulfonic anhydride
Mu-Han Liu, Wei-Ting Sun, An-Qi Yang, Zhi Wang, Zong Chang, Ai-E Wang, Pei-Qiang Huang
Topics & Concepts
ElectrophileChemistryCombinatorial chemistryFunctional groupOrganic chemistryOrganic synthesisBifunctionalSubstrate (aquarium)Reaction conditionsMoleculeElectrophilic substitutionOrganic moleculesChemical synthesisSurface modificationProtecting groupDrug discoveryFormal synthesisDerivative (finance)Reactivity (psychology)Advanced Synthetic Organic ChemistryOrganophosphorus compounds synthesisFluorine in Organic Chemistry