Cannabidiol-Driven Alterations to Inflammatory Protein Landscape of Lipopolysaccharide-Activated Macrophages <i>In Vitro</i> May Be Mediated by Autophagy and Oxidative Stress
Daniel J. Yeisley, Ahmad S. Arabiyat, Mariah S. Hahn
Abstract
Cumulatively, these data demonstrate cytotoxicity of high concentration CBD treatment. The data reported herein largely agree with other literature demonstrating the anti-inflammatory effects of CBD. However, there is discrepancy within literature surrounding efficacious concentrations and effects of CBD on specific secreted proteins. These data expand upon previous work investigating the effects of CBD on inflammatory protein expression in macrophages, as well as provide insight into the mechanism by which these effects are conferred.
Topics & Concepts
AutophagyLipopolysaccharideIn vitroChemistryLibrary scienceBiologyApoptosisImmunologyBiochemistryComputer scienceCannabis and Cannabinoid ResearchAutophagy in Disease and TherapySleep and Wakefulness Research