Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression
Christine Birdwell, Warren Fiskus, Tapan M. Kadia, Christopher P. Mill, Koji Sasaki, Naval Daver, Courtney D. DiNardo, Naveen Pemmaraju, Gautam Borthakur, John A. Davis, Kaberi Das, Sunil Sharma, Stephen Horrigan, Xinjia Ruan, Xiaoping Su, Joseph D. Khoury, Hagop M. Kantarjian, Kapil N. Bhalla
Topics & Concepts
Cancer researchApoptosisTranscription factorEnhancerBiologySynthetic lethalityDecitabineRUNX1BRD4Bystander effectEpigeneticsMedicineBromodomainImmunologyGene expressionGeneDNA methylationGeneticsDNA repairProtein Degradation and InhibitorsAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research