Plasma tRNA Fragments Derived from 5′ Ends as Novel Diagnostic Biomarkers for Early-Stage Breast Cancer
Jingyi Wang, Ge Ma, Minghui Li, Xu Han, Jin Xu, Mengdi Liang, Xinrui Mao, Xiang Chen, Tiansong Xia, Xiaoan Liu, Shui Wang
Abstract
EBC with low expression levels of tRF-Glu-CTC-003 were related to worse disease-free survival and overall survival. The identified tRFs were further examined in cell supernatants, exosomes isolated from plasma, and tissues. In conclusion, our study identified six tRFs from the 5' ends of tRNAs as novel diagnostic biomarkers for EBC, providing additional evidence for, and a better understanding of, circulating tRFs and EBC.
Topics & Concepts
Transfer RNACancerBreast cancerStage (stratigraphy)BiomarkerMolecular biologyBiologyCancer researchRNAOncologyComputational biologyInternal medicineMedicineChemistryBiochemistryGeneticsGenePaleontologyRNA modifications and cancerCancer-related molecular mechanisms researchRNA and protein synthesis mechanisms