Identification and Characterization of Defective Viral Genomes in Ebola Virus-Infected Rhesus Macaques
Rebecca I. Johnson, Beata Boczkowska, Kendra J. Alfson, Taylor E. Weary, Heather Menzie, Jenny Delgado, Gloria F. Rodriguez, Ricardo E. Carrión, Anthony Griffiths
Abstract
infections remains unknown. In this study, DVGs were detected in samples collected from EBOV- and SUDV-infected nonhuman primates (NHPs). The accumulation of these DVGs in the trailer region of the genome during infection indicates a potential role in EBOV and SUDV pathogenesis. In particular, the presence of DVGs in the testes of infected NHPs requires further investigation as it may be linked to the establishment of persistence.
Topics & Concepts
BiologyEbola virusVirologyGenomeEbolavirusIdentification (biology)Viral evolutionVirusComputational biologyGeneticsGeneBotanyViral Infections and Outbreaks ResearchViral gastroenteritis research and epidemiologyViral Infections and Vectors